Nagasaki U Link
Nagasaki University Graduate School of Biomedical Sciences 長崎大学学院医歯薬学総合研究科
 

石川泰輔 講師

自己紹介

私は東京農工大学獣医学科にて獣医学を専攻し、遺伝的要因に基づいた生命現象の出現に奥深さを感じ、東京医科歯科大学大学院分子病態分野(木村彰方教授)へと進学致しました。大学院時代には不整脈の原因遺伝子の探索に従事し、一見基礎医学と思われがちな遺伝学が臨床遺伝学へと飛躍する瞬間を目の当たりにすることができました。本研究室においても、私はラボメンバーと協調して、遺伝性不整脈の病態解明に貢献できればと考えています。


学位

  • 獣医師(2009年03月東京農工大学獣医学科)

  • 医学博士(2013年03月東京医科歯科大学大学院分子病態分野)


  • Japan Circulation Journal Award For 2013 臨床研究部門1位を受賞

  • 学術奨励賞-日本心電学会学術集会 – 青森2013

  • 九州奨励賞- 西日本生理学会 - 北九州2013

  • Furman賞 – Heart Rhythm サンフランシスコ- 2014

  • Best Moderated Poster賞- European Society of Cardiology バルセロナ2014


業績

  1. Seki A*, Ishikawa T*, Daumy X*, Mishima H, Barc J, Sasaki R, Nishii K, Saito K, Urano M, Ohno S, Otsuki S, Kimoto H, Baruteau A, Thollet A, Fouchard S, Bonnaud S, Parent P, Shibata Y, Perrin JP, Le Marec H, Hagiwara N, Mercier S, Horie M, Probst V, Yoshiura KI#, Redon R#, Schott JJ#,+, Makita N#,+. “Progressive atrial conduction system defects associated with bone malformation caused by a connexin45 mutation.” J. Am. Coll. Cardiol. 2017 (in press)
  2. Ishikawa T, Ohno S, Murakami T, Yoshida K, Mishima H, Fukuoka T, Kimoto H, Sakamoto R, Ohkusa T, Aiba T, Nogami A, Sumitomo N, Shimizu W, Yoshiura KI, Horigome H, Horie M, Makita N. “Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular non-compaction.” Heart Rhythm. 2017; 14(5) 717-724 (pdf)
  3. Ishikawa T, Tsuji Y, Makita N. “Inherited Bradyarrhythmia: A Diverse Genetic Background”. Arrhythmia 2016; 32, 352-358. doi:10.1016/j.joa.2015.09.009 (pdf)
  4. Koizumi A,  Ishikawa T, Nogami A, Fukamizu S, Sakurada H, Takahashi Y, Nakamura H, Ishikura T, Koseki H, Arimura T, Kimura A, Hirao K, Isobe M, Shimizu W, Miura N, Furukawa T. “Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur Heart J. 2015 (in press)(PubMed:26429810) (pdf)
  5. Harrell DT, Ashihara T, Ishikawa T, Tominaga I, Mazzanti A, Takahashi K, Oginosawa Y, Abe H, Maemura K, Sumitomo N, Uno K, Takano M, Priori SG, Makita N. “Genotype-dependent difference in age of manifestation and arrhythmia complication in short QT syndrome”. Int J Cardiol. 2015;190:393-402. (pdf) (Supplement) (PubMed: 25974115)
  6. Ishikawa T, Jou C, Nogami A, Kowase S, Arrington C, Barnett S, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N. “A Novel Mutation in the α-Myosin Heavy Chain Gene Is Associated with Sick Sinus Syndrome”, Circ Arrhythm Electrophysiol.2015; 8: 400-408    (pdf) (Supplement) (PubMed: 25717017)
  7. Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenobu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa S, Nakano T, Yamane Y, Kuba K, Imai Y, Saito Y, Bonne G, Kimura A. “Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations”. Cardiovasc Res  2013 Aug 1;99(3):382-94.  (pdf) (PubMed: 23631840)
  8. Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A.  “Novel SCN3B mutation associated with Brugada syndrome affects intracellular trafficking and function of Nav1.5″Circ J 2013; 77: 959-967. (pdf) (PubMed: 23257389)
  9. Ishikawa T, Sato A, Marcou CA, Tester DJ, Ackerman MJ, Crotti L, Schwartz PJ, On YK, Park JE, Nakamura K, Hiraoka M, Nakazawa K, Sakurada H, Arimura T, Makita N, Kimura A. “A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5”. Circ Arrhythm Electrophysiol 2012; 5: 1098-1107.(pdf) (PubMed: 23064965)
  10. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. “Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization”Int J Cardiol 2012; 159: 238-240. (PubMed: 22709726)
  11. Suzuki S, Fukushima R, Ishikawa TYamamoto Y, Hamabe L, Kim SYoshiyuki R, Machida N, Tanaka R. “Comparative effects of amlodipine and benazepril on left atrial pressure in dogs with experimentally-induced mitral valve regurgitation”BMC Vet Res 2012;8:166  (pdf) (PubMed: 2989022)
  12. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N.  “Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization”Circ Arrhythm Electrophysiol 2011; 4: 874-881. (pdf) (PubMed: 22028457)
  13. Suzuki S, Fukushima R, Ishikawa T, Hamabe L, Aytemiz D, Huai-Che H, Nakao S, Machida N, Tanaka R. “The effect of pimobendan on left atrial pressure in dogs with mitral valve regurgitation”J Vet Intern Med 2011; 25: 1328-1333.  (pdf) (PubMed: 22092624)
  14. Arimura T, Ishikawa T, Nunoda S, Kawai S, Kimura A, “Dilated cardiomyopathy-associated BAG3 mutations impair the Z-disc assembly and enhance the sensitivity to apoptosis in cardiomyocytes”Hum Mutat 2011; 32: 1481-1491.  (pdf) (PubMed: 21898660)
  15. Ishikawa T, Fukushima R, Suzuki S, Miyaishi Y, Nishimura T, Hira S, Hamabe L, Tanaka R “Echocardiographic estimation of left atrial pressure in beagle dogs with experimentally-induced mitral valve regurgitation”. J Vet Med Sci 2010; 73: 1015-1024.  (pdf) (PubMed: 21483182)
  16. Shichi D, Arimura T, Ishikawa T, Kimura A.  “Heart-specific small subunit of myosin light chain phosphatase activates Rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1”J Biol Chem 2010; 285: 33680-33690. (PubMed: 20801872)
  17. Ishikawa T et al. “The effect of angiotensin-converting enzyme inhibitors of left atrial pressure in dogs with mitral valve regurgitation”J Vet Intern Med 2010; 24: 342-347.  (pdf) (PubMed: 20102507)
  18. Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A.. “Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome”J Biol Chem 2009; 284: 35122-35133. (pdf) (PubMed: 19825999)
  19. Ishikawa T, Tanaka R, Suzuki S, Saida Y, Soda A, Fukushima R, Yamane Y. “Daily rhythms of left atrial pressure in beagle dogs with mitral valve regurgitation”. J Vet Intern Med 2009; 23: 824-831.  (pdf) (PubMed: 19496915)

 

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